Nanotechnolgy and microfluidics for integrated cell-material sciences

Welcome

T he Chen Group is interested in developing enabling tools based on micro- and nano-technologies for understanding how cellular microenvironmetal cues consisted with three major factors (i.e., soluble factors, insoluble factors and cell-cell interaction) regulate stem cell fate decision. Especially, understanding their mechanisms is necessary to establish a new method to obtain cell-of-interests with higher efficiency and purity for the future applications in cell-based therapy, drug screening and regenerative medicine. We believe that micro- and nano-technologies are advantageous for engineering such microenvironments as their model systems for investigating their roles. Thus, we are motivated to work on functional micro-patterns, nano-materials, bio-mimic systems as well as advanced microfluidic devices to develop new methodologies for culturing and differentiating ES/iPS cells for basic stem cell research as well as its future application .

T he Chen Group has been established in April 2008. Our research team formulates interdisciplinary research environments for creating breakthrough and new research areas. It is located in the main building of iCeMS (Complex I), which is close to the main entrance of Kyoto University.

We are hiring. Wanna join us? Click [HERE] for more information.

2010_MaN
Microphotographs of embryonic stem cells cultured on naked and nanofiber coated PDMS.
2009_la
Scanning electron micrographs of randomly distributed and aligned PMGI fibers electrospun on a PDMS layer.
2011_ANIE
Schematic representation of the self-assembly approach for the preparation of transcription factor-incorporated supramolecular nanoparticles.
2009BIT
Microphotographs of mouse embryonic fibroblast cells cultured on a PLL–PEG patterned dish surface
2011_MNE_HJ
Fluorescence images of NIH 3T3 cells cultured on AAO nanoporous samples with 50 lm PDMS square holes
Microsoft Word - 10 MNE Luo CX Revised.doc
Fluorescence image of mESCs stained with anti-nestin at day 14.
bi-layer
Photograph of a microfluidic device with a PDMS on PS bi-layer substrate.
Micrographs of Immunocytochemistry against OCT4 expressed in hESCs